SIEVE (v2.2)

Lable-free quantification of proteins/peptides, metabolites and other small molecules from high resolution/accurate mass LC-MS/MS data sets. SIEVE aligns ion chromatograms of multiple samples to identify accurate mass/retention time pairs between samples. The area under the curve of the monoisotopic peak is used for relative quantification. High resolution/accurate mass data (< 10 ppm error) generated by the Orbitrap system is required.